Asparkam - ukwakheka, izakhiwo, izinkomba zokusetshenziswa kanye nemiyalelo

Esinye sezidakamizwa zokulungisa i-arrhythmia esisebenza kahle kakhulu yi-Asparkam. Ingqikithi yesenzo sayo ukujwayelekile kwe-metabolism ne-electrolyte. I-metabolite, umthombo we-potassium ne-magnesium. Ngenxa yalokhu, ijwayele ukwenza isigqi senhliziyo. Umuthi ungowamandla entengo yeningi yentengo, kepha lokhu akuvimbeli ukuthi usebenze kakhulu kunezifaniso eziningi ezibizayo. Ama-aspark athandwa ngabasubathi ngethuba lokunciphisa amakhilogremu athe xaxa uma kuqhathaniswa nokwanda kombuso wokuphuza.

Ukwakheka

I-Asparkam iyatholakala ngesimo samaphilisi nesisombululo somjovo. Iphakethe liqukethe izingcezu ezingama-50 zamaphilisi noma ama-ampoule ayi-10 ka-5, 10 ml.

• Ithebhulethi ngayinye iqukethe i-0.2 g ye-potassium ne-magnesium, kanye nezinto zokuxhuma i-cachet.
• Isixazululo se-Asparkam siqukethe i-anhydrous magnesium aspartate - 40 mg ne-potassium - 45 mg. Lokhu kulingana no-3 mg we-magnesium emsulwa kanye no-10 mg we-potassium emsulwa. Ngaphezu kwalokho, ifomu lomjovo liqukethe i-sorbitol namanzi.

I-Potassium ihlinzeka ngokuhamba kwemizwa yezinzwa, ikhombisa izakhiwo zomchamo futhi idlala indima enkulu ekunciphiseni kwemisipha. I-Magnesium inesibopho somsebenzi we-enzymatic, ibamba iqhaza ekuthuthweni kwama-ion nokukhula kwamaseli.

Indlela yokusebenza ukulungisa izinqubo ze-metabolic nge-potassium ne-magnesium. Lezi zinto zinqoba kalula ulwelwesi lweseli futhi zenzele ukushoda kwama-microelements alahlekile ngaphansi kwethonya lesikhathi noma ushintsho lwe-pathological. Ibhalansi ejwayelekile ye-electrolyte iholela ekwehleni kokusebenza kwe-myocardium, icime ukujabula kwayo futhi ivumele imizwa kagesi yohlelo lokuqhuba inhliziyo isebenze ngendlela ejwayelekile.

Ngesikhathi esifanayo, izinqubo ze-metabolic ziyathuthuka, ukuthambekela kwe-myocardium kuma-glycosides enhliziyo kuba ngcono, ngoba ubuthi bawo buyehla kakhulu. Imikhumbi ye-Coronary nayo iyaphendula kuzinguquko ezenzekayo, ngoba ukuthambekela okujwayelekile kwesigqi senhliziyo kuzivumela ukuthi zinikeze ngegazi elilungile kwizitho nezicubu ezinomsoco nomoya-mpilo.

Ama-Magnesium ions enza kusebenze i-ATP, elinganisa ukugeleza kwe-sodium esikhaleni esiphakathi kwamaseli kanye ne-potassium esikhaleni se-intracellular. Ukwehla kokuhlushwa kukaNa + ngaphakathi kweseli kuvimbela ukushintshaniswa kwe-calcium ne-sodium emisipheni ebushelelezi yemisipha, ebenza bakhululeke ngokuzenzakalela. Ukukhula kwe-K + kukhuthaza ukukhiqizwa kwe-ATP - umthombo wamandla, i-glycogen, amaprotheni kanye ne-acetylcholine, evimbela ischemia yenhliziyo kanye ne-hypoxia yeselula.

I-Asparkam ingena egazini ngokusebenzisa umgudu wokugaya ukudla, futhi ukusuka lapho - ngesimo se-aspartate ku-myocardium, lapho iqala ukusebenza khona ukwenza ngcono imetabolism.

Izici

Kungenxa yomphumela ohlangene we-potassium ne-magnesium emisipha yenhliziyo futhi kusiza ukuyibuyisa ngemuva kokuhlaselwa yinhliziyo. I-K + ithuthukisa ukuthinteka kwenhliziyo ngokunciphisa ukujabula nokwenza ngcono ukuqhutshwa kwemisipha. Kwandisa ukukhanya kwezitsha ezinkulu zenhliziyo. I-Magnesium ivuselela ukuhlanganiswa kwama-amino acid adingekayo ukugcwalisa ukukhubazeka kwezicubu zomzimba futhi ivuselele ukuhlukaniswa kwamaseli, okufaka isandla ekuvuseleleni okusheshayo.

Lezi zakhiwo zisetshenziselwa ukwelashwa kwe-glaucoma kanye nengcindezi ephezulu yokungasebenzi. Ukujwayelekile kwe-metabolism kanye ne-electrolyte balance kunciphisa cishe zonke izimpawu ezingezinhle ezihambisana nokugcwala ngokweqile kwemithambo. Umphumela wecala ukukhula ngokushesha kwemisipha, okukhombise ukuthi kubalulekile kubadlali. Ngakho-ke, i-Asparkam ithandwa kakhulu kwezemidlalo yamandla.

I-potassium ne-magnesium

Izazi ze-Cardiologists zihlala zikhuluma ngokubaluleka kwalezi zinto zokulandela umkhondo. Akukho lutho olumangazayo kulokhu. Isigqi sezinciphiso zenhliziyo sinqunywa umsebenzi osezingeni eliphakeme wohlelo lokuqhuba lwe-myocardial, lapho kutholakala khona imizwa ngokuzimela, futhi, ngokudlula inqwaba yemicu ekhethekile yezinzwa, kusebenze imvamisa yokuncipha kwe-atria nama-ventricles ngokulandelana okuthile. Ukusebenza okujwayelekile kwale micu kuncike ekugxileni kwe-magnesium ne-potassium kuzo.

Ukushaya kwenhliziyo kujwayelekile, okusho ukuthi lowo muntu uzizwa kahle futhi, ngoba isitho ngasinye sithola umsoco ofanele kanye ne-oxygen ngesikhathi nangendlela elandelanayo ecacile. Ngokushoda kwe-magnesium, izinkinga ziqala ezitsheni ze-coronary. Ziyathamba futhi zibe banzi. Ngenxa yalokhu, igazi linciphisa ukuhamba kwalo, izitho ziqala ukuzwa ukungaphatheki kahle, futhi isiguli siqala ukuzizwa sibi kakhulu.

Umphumela ohlukile ubonwa nge-potassium eyeqile: ama-coronaries aba ntekenteke futhi anciphile. Kepha lokhu futhi kuletha ezinye izinkinga ekugelezeni kwegazi, ngoba igazi alinakungena emigwaqweni emikhulu ngobuningi bese limpontshelwa ezithweni. Ukulahleka kwe-magnesium ngamaseli, ukukhishwa kwayo esikhaleni samaseli kufaka phakathi ukubhujiswa kwama-carbohydrate ayinkimbinkimbi, i-hyperkalemia yenzeka.

I-Magnesium ibamba iqhaza kuzo zonke izinqubo ze-metabolic ngaphandle kokukhetha. Kuyisisekelo sokuhlukaniswa kwamaseli, ukuhlanganiswa kwe-RNA, futhi kunikeze ibhukhimakhi lemininingwane yefa. Kepha uma ukugxila kwayo kuncipha, ulwelwesi lweseli luba isithiyo esingenakunqobeka entweni yokulandela umkhondo. I-Asparks magnesium isiza ukungena kuyo ngenani elengeziwe le-elementi.

Kunezingibe lapha. Ukweqisa izidakamizwa kuhambisana ne-hypermagnesemia, futhi lokhu kuyimbangela yokuboshwa kwenhliziyo. Ngakho-ke, ukuzitholela ngokwakho umuthi "ongenangozi" akwamukelekile.

Ukuhlushwa kwe-potassium ne-magnesium esitokisini kubaluleke kakhulu ngesikhathi sokukhulelwa. Baqinisekisa ukukhula okuzinzile nokukhula kombungu. Kepha i-Asparkam inikezwe abesifazane abakhulelwe ngokucophelela okukhulu, bekhetha i-Panangin yaseJalimane - uvithamini wenhliziyo. Izimpawu zokudlula ngokweqile zifaka ukukhathala kanye ne-dysuria.

Enye i-nuance: ukungabi khona kwe-potassium kushintsha ukujabula kwemizwa, nokushoda kwe-intracellular magnesium kubangela ukungalingani esizukulwaneni nasekusebenziseni amandla, okuvuselela ukudlikizela, ukuba ndikindiki kwemilenze, nobuthakathaka.

Izinkomba zokuthatha i-Asparkam

Umsebenzi oyinhloko we-Asparkam ukuthuthwa kwezinto zokulandela umkhondo ungene esitokisini. Isidakamizwa sinqunywe ezimweni ezilandelayo:

• Ukushoda kwe-K + ne-Mg + emzimbeni.
• Ukuphazamiseka kwesigqi senhliziyo.
• Ischemic heart disease, postinfarction isimo.
• I-Extrasystole yama-ventricles.
• Ukungabekezelelani kweFoxglove.
• Isimo sokushaqeka.
• Izifo ezingapheli zokujikeleza kwegazi.
• I-Atrial fibrillation.
• Ukwehluleka kwenhliziyo.
• Kusukela ezinyangeni ezine kunconywa ngokuhlangana ne-Diacarb ukulungisa ingcindezi yokungasebenzi. Le nhlanganisela isetshenziselwa ukwelapha i-glaucoma, isithuthwane, i-edema, i-gout.

Ezemidlalo

Lokhu akusho ukuthi i-Asparkam inomthelela omkhulu ekuzuzeni izicubu zomzimba. Ngakho-ke, ngombono, kwezemidlalo akusona isidakamizwa sokuzikhethela. Kepha, noma kunjalo, ukuthandwa kwayo phakathi kwabasubathi kukhulu. Incazelo ilula: lapho bethola amakhilogremu athe xaxa, abagijimi badla inani elikhulu lama-calories ngesimo samaprotheni, ama-carbohydrate, namafutha. Ngasikhathi sinye, ukulandelela izakhi ze-akhawunti kwengxenye encane kakhulu yokudla. Ngokusobala akwanele ngomsebenzi ojwayelekile wenhliziyo. Ngaphezu kwalokho, ukuntuleka kwe-potassium ne-magnesium kuholela ekukhathaleni okuphezulu ngenxa yokungalingani komzimba. Ama-aspark kuleli cala awanakubuyiselwa.

Ihlanganisiwe, isebenziseka kalula futhi igcwele ukulungiswa okudingekayo kwe-K + ne-Mg +:

1. Kwehlisa ukukhathala.
2. Inxephezela ngokushoda kwe-micronutrient.
3. Khulula ubuthakathaka bemisipha.
4. Kwenza umsebenzi we-myocardium uzinze.
5. Kushukumisa ukukhuthazela.
6. Ivimbela i-AMI ne-ONMK.

Ukwakha umzimba

Ngokuqondene nokwakha umzimba, lapha i-Asparkam isebenza njenge-metabolite enhle kakhulu. Kusekuqeqeshweni kwamandla lapho kudingeka khona imiphumela yaso yokwakha imisipha. I-Potassium inomphumela omuhle ekusheshisweni kokuphendula komzimba, i-magnesium ibandakanyeka ku-protein metabolism. Kulokhu, ukukhula kwamaseli kwenzeka ngaphandle kokuqongelelwa kwamafutha nokugcinwa koketshezi emzimbeni. Leli iphuzu elibaluleke kakhulu, ngoba ngesikhathi sokuziqeqesha, abagijimi basebenzisa inani elikhulu lamanzi, eligeza izakhi zokulandela umkhondo. Lokhu kusho ukuthi ukugcwaliswa kwabo kabusha kuba yisidingo esiphuthumayo.

Ukwehla kwesisindo

Ukuqonda kokuthatha lesi sidakamizwa kusekelwe kuzakhiwo ezifanayo esezivele ze-magnesium ne-potassium. I-Mg + iyadingeka ngesistimu yezinzwa emaphakathi, kanti i-K + isiza yonke imisipha emzimbeni. Ndawonye balungisa ibhalansi kasawoti wamanzi, basuse ukuvuvukala. Ngenxa yalesi sici, i-Asparkam isetshenziselwa ukunciphisa umzimba: ukuhoxiswa koketshezi emzimbeni kukuvumela ukuthi wehlise isisindo. Ngesikhathi esifanayo, inani lamafutha omzimba lihlala lingashintshiwe, ngakho-ke umuthi awukaze ube ngezindlela ezisiza ukunciphisa umzimba. Ukuyithatha ungacabanganga kuyingozi, ngoba iyi-metabolite, futhi imetabolism yinto ecashile kakhulu. Ukweqiwa kwezinto zokulandela umkhondo kuhlanganisa nemiphumela engathandeki, kepha akusheshisi neze izindlela zokwenziwa komzimba.

Ukungafani nendlela yokuphatha

Kunokuphikisana okumbalwa, kepha kubalulekile:

• Ukungabekezelelani komuntu ngamunye noma ukuzwela komzimba.
• Ukungasebenzi kahle kwezindlala nezinso ze-adrenal.
• I-Myosthenia.
• Ukushaqeka kwe-Cardiogenic.
• Ukuvinjelwa ama-degree angama-2-3.
• I-Metabolic acidosis.
• I-ARF nokwehluleka kwezinso okungamahlalakhona, i-anuria.
• I-hemolysis.
• Ukuphela kwamanzi emzimbeni.
• Ubudala ngaphansi kwe-18.

Ithonya le-Asparkam emzimbeni alizange lifundwe ngokuningiliziwe. Ngalesi sizathu, isetshenziswa ngokuqapha ngesikhathi sokukhulelwa futhi ayinqunyelwe izingane. Iziguli esezikhulile nazo zisengozini, ngoba umzimba wazo wehliswa ijubane ngenxa yezinguquko ezihlobene nobudala. Kodwa-ke, ezifweni zohlelo lwe-cardiovascular, i-ejenti yamukelwa ukwamukelwa ngaphandle kwemingcele. Indlela ejwayelekile ukuthatha amaphilisi ambalwa kathathu ngosuku ngemuva kokudla.

Okuqhamuka uma udla imishanguzo

I-Asparkam ayinayo imiphumela emibi kuphela, kepha futhi inemibi. Ziboniswa yizimpawu ezilandelayo:

Ukuzizwa ubuthakathaka, ubuthakathaka, isiyezi.

• Ubuthakathaka bemisipha.
• Ukuqhuma kwesikhumba.
• Isicanucanu.
• I-Dyspepsia.
• Umlomo owomile.
• Ukuqhakaza.
• I-Hypotension.
• I-Hyperhidrosis.
• I-Dyspnea.
• I-vein thrombosis.

Ngaphezu kwalokho, ukweqisa izidakamizwa kungenzeka, okuzibonakalisa:

• i-hyperkalemia;
• i-hypermagnesemia;
• izihlathi ezibomvu;
• ukoma;
• i-arrhythmia;
• ukudlikizela;
• i-hypotension yemithambo;
• inhliziyo block;
• ukucindezelwa kwesikhungo sokuphefumula ebuchosheni.

Lezi zimpawu zidinga usizo lwezokwelapha. Ngokuvamile, ukusetshenziswa kwesikhathi eside kwe-Asparkam kudinga ukuqapha amazinga e-electrolyte, ngoba:

1. ukuphepha ngokuphelele komuthi akukaze kufakazelwe;
2. uma ihlanganiswe ne-tetracyclines, i-iron ne-fluorine, umuthi uvimbela ukumuncwa kwawo (isikhathi esiphakathi kwemithi kufanele okungenani sibe ngamahora amathathu);
3. kunengozi yokuhlaselwa yi-hyperkalemia.

Ukuhambisana

Inokugxila okuhlukile. Ngokombono we-pharmacodynamics, ukuhlanganiswa ne-diuretics, i-beta-blockers, i-cyclosporins, ama-NSAID, i-heparin ivuselela ukuthuthukiswa kwe-asystole ne-arrhythmia. Inhlanganisela yamahomoni iyamisa lesi simo. Ama-ion e-potassium anciphisa umphumela omubi we-glycosides yenhliziyo. Magnesium ion - neomycin, streptomycin, polymyxin. I-calcium inciphisa umsebenzi we-magnesium, ngakho-ke udinga ukuhlanganisa lezo zimali ngokucophelela okukhulu, ngenxa yezizathu zempilo.

I-Pharmacokinetics ixwayisa ngokungahambelani kwe-Asparkam ngezidakamizwa ezisebenza ngama-astringent kanye ne-coating, ngoba zinciphisa ukumuncwa komuthi kuthubhu yokugaya futhi zincoma, uma kunesidingo, ukugcina ikhefu lamahora amathathu phakathi kwemithamo.

Ukuqhathanisa nePanangin

I-Potassium ne-magnesium nayo iyatholakala komunye umuthi odumile. Sikhuluma ngePanangin. Izici zokuqhathanisa zemithi zivezwa etafuleni.

Kusobala ukuthi izinto ezisebenzayo kuzo zombili lezi zidakamizwa ziyefana, umehluko usekhakheni, elingathinti ukwelashwa kwemithi. Kodwa-ke, iPanangin inolwelwesi lwefilimu oluvikela i-mucosa yesisu namazinyo kubuthi bamakhemikhali be-ejenti. Ngakho-ke, wonke umuntu onezinkinga ngohlelo lokugaya ukudla unconywa iPanangin, intengo yayo iphindwe kaningana kunezindleko ze-Asparkam.

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