Igama lesiLatini lomuthi nguRegaine. I-Minoxidil
Yini iRegaine?
I-Regaine iyindlela yokwelashwa ye-alopecia (impandla) kwabesilisa nabesifazane.
Incazelo yefomu lokulinganisa
I-Regaine iyatholakala ngesisombululo sokusetshenziswa kwangaphandle. Kungaba yi-2% ne-5%. Lesi sixazululo sisobala futhi sinombala ophuzi okhanyayo noma ongenambala ngokuphelele. Ifakwe emabhodleleni angama-60 ml. Iphakheji iqukethe nemibhobho emithathu: umlomo wombhobho wokufafaza, umlomo wombhobho wokuhlikihla, kanye nembhobho yesifutho enwetshiwe. Ukwakheka komuthi, ngaphandle i-minoxidil 5 kususelwa ku-ethanol, propylene glycol namanzi ahlanziwe.
umphumela wemithi
I-Regaine yisidakamizwa esinomthelela oshukumisayo ekukhuleni kwezinwele kubantu abahlushwa i-androgenic alopecia. Ngemuva kwezinyanga ezi-4 zokusetshenziswa okujwayelekile komuthi kuphawulwa izimpawu zokukhula kwezinwele. Kumele kuqashelwe ukuthi ukuqala nobukhali balo mphumela kungahluka kuye ngesiguli kuya kwesiguli. Imiphumela esheshayo itholakala ngesisombululo esingu-5% sokuphinda uthole ikhambi, uma kuqhathaniswa nesisombululo esingu-2%. Lokhu kuye kwaphawulwa ngezinga elikhulile lokukhula kwezinwele ze-vellus. Kodwa ngemuva kokuqedwa kokusetshenziswa komuthi, kukhona ukumiswa kokukhula kwezinwele ezintsha, futhi ezinyangeni eziyi-3-4 ezizayo, amathuba okubuyisa ukubukeka kwangempela ayanda. Indlela yokusebenza yeRegaine ekwelapheni i-androgenic alopecia ayiqondakali kahle.
I-Pharmacokinetics
I-Minoxidil ayishutheki kahle esikhunjeni esijwayelekile futhi esiqinile uma isetshenziswa ngaphandle. Le nkomba imaphakathi no-1.5%, futhi inani layo eliphezulu lingafinyelela ku-4.5%. Labo. yi-1.5% kuphela yedosi esetshenzisiwe engangena ekusakazweni kwesistimu. Umphumela wezifo zesikhumba ezihambisanayo ekumungeni komuthi uhlala ungaziwa.
Kuze kube manje, iphrofayli ye-biotransformation ye-metabolic ye-minoxidil ebuyayo ngemuva kokufaka isicelo sangaphandle ayifundwanga ngokuphelele.
I-Minoxidil ayingeni kwi-BBB futhi ayibopheli amaprotheni egazini le-plasma.
Cishe i-95% ye-minoxidil engena ekusakazeni kwesistimu ikhishwa ezinsukwini ezine ezilandelayo ngemuva kokumisa ukusetshenziswa komuthi.
I-Regaine ikhishwe kakhulu emchameni. Lokhu kwenzeka ngokuhlunga okukhazimulayo.
Ngosizo lwe-hemodialysis, i-minoxidil nama-metabolites ayo akhishwa emzimbeni.
Izinkomba zomuthi
Inkomba yokusetshenziswa kokuphinda uthole i-alopecia ye-androgenic, kokubili kwabesilisa nabesifazane. Kunqunyelwe ukuzinzisa ukulahleka kwezinwele, kanye nokubuyisa isikhumba.
Izimo
I-Regaine akufanele isetshenziswe yizingane nentsha engaphansi kweminyaka engu-18 ubudala, kanye neziguli ezingaphezu kweminyaka engama-65 ubudala. Ukwephula ubuqotho kanye nezikhumba zekhanda, ukuzwela kuzakhi zezidakamizwa nakho kuyaphikisana.
Isicelo ngesikhathi sokukhulelwa kanye lactation
Ngaphandle kweqiniso lokuthi umphumela wokuphinda ubuye esigulini ngesikhathi sokukhulelwa kanye ne-lactation awaziwa, akufanele usetshenziswe. Ngokusetshenziswa okujwayelekile, i-minoxidil iyangena futhi ikhishwe obisini lwebele.
Imiphumela emibi yomuthi
Ucwaningo lwezemitholampilo lukhombisile ukuthi i-dermatitis, eyenzeka ekhanda, ingaba nomphumela oseceleni. Ngokuvamile, ukuvuvukala, ukuxebuka, ubomvu kubonakala.
I-allergen yokuxhumana ne-dermatitis nokunwaya kwesikhumba, i-alopecia ne-folliculitis akuvamile.
Kumele kuqashelwe ukuthi imiphumela emibi ivame ukubonakaliswa lapho usebenzisa ukuthola kabusha ngesisombululo se-5%.
Futhi, uma usebenzisa lesi sidakamizwa, i-rhinitis yokungezwani komzimba nokuphefumula okuncane, isiyezi kanye nekhanda, i-neuritis, ukuguquguquka kwengcindezi yegazi nokushaya kwenhliziyo, ubuhlungu besifuba, ushintsho kwisigqi sezingcindezi zenhliziyo kungenzeka. Kodwa ukuxhumana okucacile phakathi kokusetshenziswa kwezidakamizwa kanye nokuvela kwemiphumela emibi kuphawuliwe, okokuqala, nokusabela kwesikhumba.
Ukweqisa ngokweqile
Ukweqisa ngokweqile kungenzeka uma ngephutha uthatha iRegaine ngaphakathi. Lokhu kubangela umphumela ohlangothini oluhlelekile, ngenxa yezici ze-vasodilating zengxenye eyinhloko yomuthi, i-minoxidil.
Izimpawu zalesi simo zifaka i-tachycardia, ukwehla kwengcindezi yegazi nokugcina uketshezi.
Uma kwenzeka ukweqisa ngokweqile, kuyadingeka ukuthi ufune usizo lwezokwelapha ukunikezela ngemithi enganikeza ukumelana.
Indlela yokuphatha kanye nomthamo
I-Regaine yenzelwe ukusetshenziswa kwangaphandle kuphela ekhanda. Akunconywa ukuthi uyisebenzise kwezinye izingxenye zomzimba.
Umthamo ophelele wansuku zonke womuthi akufanele weqe u-2 ml, kungakhathalekile ukuthi iyiphi indawo yendawo ethintekile. Kunconywa ukuthi uhlukanise le mali ibe yimithamo emi-2 ye-1 ml. Ukuthola kabusha kufanele kusetshenziswe kusuka maphakathi nesilonda kuya emaphethelweni.
Kunconywa ukuthi kusetshenziswe isisombululo esingu-5% kuphela uma isiguli esisebenzisa isisombululo esingu-2% singenayo imiphumela eyanelisayo yezimonyo ekukhuleni kwezinwele, futhi umphumela osheshayo uyathandeka.
Abesifazane bayelulekwa ukuthi basebenzise lo muthi ekulahlekelweni izinwele engxenyeni ephakathi. Ngakolunye uhlangothi, abesilisa basebenzisa regaine lapho ukwehla kwezinwele kwenzeka emqheleni. Kulezi zindawo, umuthi usebenza kahle kakhulu.
Thenga uphinde uthole, bese-ke kufanele lisetshenziswe esikhunjeni esomile. Indlela yesicelo incike kofake isicelo osetshenzisiwe. Uma lesi sidakamizwa sisetshenziswa kalula, kufanele sigezwe kahle ngemuva kokwelashwa kwekhanda.
Uma i-regaine ifakwa ngebhodlela le-spray, qala ususe ikepisi elikhulu elingaphandle ebhodleleni, kanye nekepisi lesikulufa sangaphakathi. Lapho-ke kuyadingeka ukufaka umbhobho odingekayo (isifutho) ebhodleleni bese uluqinisa kahle. Ngenhloko yombhobho enkabeni yendawo ezokwelashwa, fafaza i-ejenti bese uyisabalalisa ngokulinganayo ngezandla zakho. Kwanele ukuphinda lezi zinyathelo izikhathi eziyisithupha (1 ml).
Uma indawo ethintekile incane noma ngaphansi kwezinwele ezisele, kungcono ukusebenzisa umbhobho wesifutho oweluliwe. Izinyathelo zokuqala ekusebenziseni lesi sinanyathiselwa ziyefana nezimo zangaphambilini. Bese ususa ikhanda elincane lokufafaza kusuka kusibhamu sokufafaza bese uqinisa umbhobho wokusabalalisa onwetshiwe. Ukulungiselela okufakiwe kufanele futhi kusatshalaliswe yonke indawo ngezandla zakho futhi le nqubo kufanele iphindwe izikhathi eziyisithupha.
Ukusetshenziswa ezindaweni ezincane zempandla, sebenzisa umbhobho wokuhlikihla. Yifake ebhodleleni, uyiqinise uqinise, bese ucindezela ibhodlela ukuze ugcwalise ikamelo eliphezulu kulayini omnyama (1 ml). Ngemuva kwalokho, ngokunyakazisa umzimba, lesi sidakamizwa sisetshenziswa endaweni ethintekile yekhanda.
imiyalelo ekhethekile
Ngaphambi kokusebenzisa iRegaine, kufanele uhlolwe ngokuphelele ukuze uqiniseke ukuthi isikhumba sasekhanda siphilile.
Ukusetshenziswa kwezidakamizwa kufanele kunqamuke uma kwenzeka ukusabela okunzima kwesikhumba nemiphumela emibi.
Imigomo nemibandela yesitoreji
Impilo yeshalofu ye-regain incike ekugxileni kwesisombululo: isixazululo se-5% sigcinwa iminyaka emi-5, 2% - iminyaka emithathu. Gcina umuthi endaweni eyomile lapho izingane zingafinyeleleki khona, lapho izinga lokushisa lingeqi ku-25 ° C.
