I-Histidine ingumkhiqizo wamaprotheni we-hydrolysis. Amaphesenti alo amakhulu (angaphezu kuka-8.5%) atholakala egazini i-hemoglobin. Okokuqala kwatholakala ngo-1896 kusuka kumaprotheni.
Yini i-Histidine
Kuyaziwa ukuthi inyama ingumthombo wamaprotheni ezilwane. Eyokugcina nayo iqukethe ama-amino acid. Isibonelo, i-histidine, okungenakuphila kwayo emhlabeni. Le proteinogenic amino acid ibamba iqhaza ku-protein genesis futhi ithinta imetabolism.
Ama-amino acid asetshenziselwa ukwenza amaprotheni. Omunye umzimba uthola inqubo yokugaya ukudla. Ezinye zazo azinakubuyiselwa endaweni, ezinye umzimba uyakwazi ukuzihlanganisa wedwa. Ngokumelene nesizinda esijwayelekile, i-histidine ivelele, ehlanganisa izici zawo womabili amaqembu. Kubizwa kanjalo - i-amino acid ebalulekile.
Umuntu uhlangabezana nesidingo esikhulu kakhulu se-histidine ebuntwaneni. I-amino acid ebisi lwebele noma ifomula ikhuthaza ukukhula. Akubalulekanga kangako entsheni nasezigulini ezisenqubweni yokuvuselelwa.
Ngenxa yokondleka okungalingani kanye nengcindezi, ukushoda kwe-histidine kungaqala. Ebuntwaneni, lokhu kusongela ukuphazamiseka kokukhula nokuma ngokuphelele. Kubantu abadala, i-rheumatoid arthritis iyaqala.
Imisebenzi ye-amino acid eyingqayizivele
I-Histidine ikhombise izakhiwo ezimangazayo. Isibonelo, iyakwazi ukuguqula ibe yi-hemoglobin ne-histamine. Uhlanganyela umzimba, kunomthelela izicubu oxygenation. Iphinde isuse izinto ezinobungozi futhi inyuse izinga lokuzivikela.
Eminye imisebenzi:
- ilawula igazi pH;
- kusheshisa ukuvuselelwa;
- uxhumanisa izindlela zokukhula;
- ubuyisela umzimba ngendlela yemvelo.
Njengoba sekushiwo, ngaphandle kokukhula kwe-histidine, ukuphulukiswa kwezicubu kanye nempilo uqobo akunakwenzeka. Ukungabi bikho kwayo kuholela ekuvukeleni kolwelwesi lwamafinyila nesikhumba.
Ukululama ngemuva kokuhlinzwa kuthatha isikhathi eside. Ukungena emzimbeni, i-amino acid inikeza ukwelashwa okuphumelelayo kwezifo ezihlangene.
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Ngaphezu kwalezi zakhiwo, i-histidine iyabandakanyeka ekwakhekeni kwe-myelin sheaths ye-neurons. Ukulimala kokugcina kuhlanganisa ukonakala kwesimiso sezinzwa. Ukuhlanganiswa kwama-leukocyte nama-erythrocyte, ancike ekuvikelekeni komzimba, akunakwenza ngaphandle kwe-amino acid. Ekugcineni, impahla ebingalindelekile kakhulu ukuvikelwa kuma-radionuclides.
Indima ye-histidine kwezokwelapha
Ucwaningo lokuthi kungenzeka yini ukuthi le nto isenziwa. Kodwa-ke, kuyaziwa vele ukuthi kuyasiza ukwehlisa umfutho wegazi. Khulula imithambo yegazi, ivikela umfutho wegazi ophezulu, ukuhlaselwa yinhliziyo, isifo sokuqina kwemithambo yegazi nezinye izifo. Ukusebenza kwe-amino acid ekulweni nokuphazamiseka kwesistimu yenhliziyo kufakazelwe ngokwesayensi (kunciphisa ubungozi ngo-61%). Isibonelo sesifundo esinjalo singatholakala lapha.
Enye indawo yesicelo yi-nephrology. I-Histidine ithuthukisa isimo seziguli ezinezifo zezinso. Ikakhulukazi asebekhulile. Kubaluleke kakhulu ekwelapheni izifo zamathumbu nezesibindi. Kuboniswa nge-arthritis, i-urticaria kanye ne-AIDS.
Izinga lansuku zonke le-histidine
Ngezinhloso zokwelapha, imithamo ebangeni le-0.5-20 g / ngosuku isetshenzisiwe. Ukwanda kokusetshenziswa (kuze kufike ku-30 g) akubandakanyi imiphumela emibi. Noma kunjalo, ukwamukelwa okunjalo akunakwandiswa isikhathi eside. Umthamo ongekho ngaphezu kuka-8 g / ngosuku wanele futhi uphephile.
Ifomula ikuvumela ukuthi ukhethe isilinganiso esifanele se-histidine: 10-12 mg / 1 kg (isisindo somzimba).
Ukusebenza okuphezulu, i-amino acid njengesengezo sokudla kufanele isetshenziswe esiswini esingenalutho.
Ukuhlanganiswa nezinye izinto
Ngokocwaningo oluthile olwenziwe, inhlanganisela ye-histidine ne-zinc iyikhambi eliphumelelayo. Lesi sakamuva siqinisekisa ukumuncwa kalula kwe-amino acid emzimbeni.
Abantu abangama-40 babambe iqhaza kulolu cwaningo. Phakathi nocwaningo, kwavela ukuthi ukuhlanganiswa kwe-zinc ne-amino acid kunciphisa ukubonakaliswa kwezifo zokuphefumula. Isikhathi sabo sincishisiwe ngezinsuku eziyi-3-4.
Ama-nuances wohlelo lokusebenza
I-Histidine ngesimo sezithako zokudla inqunyelwe iziguli esikhathini sangemva kokuhlinzwa. Futhi nakubantu abaphethwe i-anemia ne-arthritis. Lapho kukhona ukuphazamiseka kwe-bipolar, i-asthma kanye ne-allergies, amalungiselelo e-amino acid aphikisiwe. Ukuqapha kufanele kuthathwe lapho kuthatha izithasiselo ngokufakwa kwabesifazane abakhulelwe nabancelisayo. Futhi esimweni sokushoda kwe-folic acid emzimbeni.
I-Histidine ibalulekile ekucindezelekeni, ekuhlukumezekeni, ezifweni ezingamahlalakhona nasekuzikhandleni okuphezulu. Kubalulekile kubasubathi. Kulezi zimo, imithombo yokudla ngeke ihlangabezane nesidingo. Izithako zokudla ziba yisixazululo senkinga. Kodwa-ke, umthamo onconyiwe akufanele weqiwe. "Ukuphendula" komzimba kungaba ukungasebenzi kahle kokugaya ukudla kanye nokwehla kwe-asidi.
Isifo se-Amino acid metabolism yisifo esingajwayelekile sokuzalwa (i-histidinemia). Kubonakala ngokungabikho kwe-enzyme ethize elulazayo. Umphumela uba ukwanda okukhulu kokuhlushwa kwe-histidine kuketshezi lomzimba nomchamo wesiguli.
Ingozi yokushoda nokudlula ngokweqile
Ucwaningo lukhombisile ukuthi ukushoda kwe-histidine kubanga isifo samathambo. Ngaphezu kwalokho, izifo ziphathwa ngale-amino acid. Ebuntwaneni, ukuntuleka kwe-histidine kungadala i-eczema. Ukungasetshenziswa ngendlela ehlelekile kwento kubangela uketshezi lwamehlo, izifo zesisu kanye ne-duodenum. Engxenyeni yamasosha omzimba - ukungezwani komzimba nokuvuvukala. Ukushoda nakho kuholela ekukhuleni okungahleliwe, kwehle ucansi lokushayela, kanye ne-fibromyalgia.
I-Histidine ayiyona into enobuthi. Kodwa-ke, ukweqisa kwayo kuholela ekungezelweni komzimba, i-asthma, amazinga aphezulu e-cholesterol. Ukudla ngokweqile kwe-amino acid ngabesilisa kuyimbangela yokuphuma ngaphambi kwesikhathi.
Yikuphi ukudla okuqukethe i-histidine
Isidingo sansuku zonke se-histidine sihlanganiswa ngokuphelele yisethi yokudla. Ukudla kokudla kuyalinganiselwa. Izibonelo (mg / 100 g).
| Umkhiqizo | Okuqukethwe kwe-Histidine, mg / 100 g |
| Ubhontshisi | 1097 |
| Inkukhu yebele | 791 |
| Inkomo | 680 |
| Inhlanzi (isalmon) | 550 |
| Amagciwane kakolweni | 640 |
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Ibhalansi ye-amino acid emzimbeni womuntu omdala igcinwa kalula ngokuhlanganiswa kwayo. Izingane zidinga ukunikezwa njalo kwe-histidine kusuka emithonjeni yangaphandle. Ngakho-ke, imenyu elinganiselayo iyinto ebaluleke kakhulu ekukhuleni okunempilo.
Okuqukethwe kwama-amino acid ekudleni kwamaprotheni kuyakwazi ukuhlangabezana nezidingo zamanje zezinhlelo zomzimba. Imikhiqizo yezilwane ifaka amaprotheni "aphelele". Ngakho-ke, zibaluleke kakhulu.
Ukudla kwezitshalo akuqukethe uhla oluphelele lwezakhamzimba ezibalulekile. Kulula ukugcwalisa insiza ye-histidine. Uma kunesidingo, ukusetshenziswa kwemikhiqizo yamaqembu ahlukene kuyadingeka.
Amarekhodi aphethe okuqukethwe kwe-amino acid:
- inhlanzi;
- inyama;
- ubisi nezithako zalo;
- okusanhlamvu (ukolweni, irayisi, ilayisi, njll.);
- ukudla kwasolwandle;
- imidumba;
- inkukhu kanye nezagwaca amaqanda;
- okusanhlamvu kwe-buckwheat;
- amazambane;
- amakhowe;
- izithelo (ubhanana, izithelo ezisawolintshi, njll.).
Isidingo sansuku zonke se-histidine singakhokhelwa ngokudla kwasolwandle kanye nanoma yiluphi uhlobo lwenyama (ngaphandle kwewundlu). Futhi noshizi namantongomane. Ukusanhlamvu, kufanele ukhethe i-buckwheat, irayisi lasendle noma i-millet.
Ukubuyekezwa kwezithako zokudla ezine-histidine
| Igama elengeziwe | Isikali, mg | Ifomu lokukhishwa | Izindleko, ama-ruble | Ukupakisha isithombe |
| I-Twinlab, i-L-Histidine | 500 | Amaphilisi angama-60 | Cishe ngo-620 | |
| I-OstroVit Histidine | 1000 | Amagremu ayi-100 we-powder | 1800 |  |
| I-MyProtein Amino Acid 100% L-Histidine | Ayikho idatha | Amagremu ayi-100 we-powder | 1300 |
Isiphetho
Inani le-histidine alinakulinganiswa ngokweqile. Kubalulekile ekukhuleni okunempilo komzimba okhulayo. Ngaphandle kwalokhu i-amino acid, amangqamuzana egazi nama-neurons awakhiwa. Inikeza ukuvikelwa emisebeni yemisebe, isiza ukususa izinhlanganisela zensimbi esindayo.
Ukudla kwansuku zonke kudinga ukunakekelwa okusondele. Ikuvumela ukuthi ugcine izinsizakusebenza namandla omzimba ezingeni elifanele. Ukudla okunothe ngomlando kubalulekile ezinganeni, ebusheni nasezigulini zangemva kokuhlinzwa. Ukusebenza kwe-amino acid ebaluleke kakhulu kuye kwafakazelwa ngokwesayensi. Ngaphandle kwayo, impilo yomuntu kanye nokuphila uqobo emhlabeni akunakucatshangwa.
