I-Tyrosine - indima emzimbeni nezakhiwo ezizuzisayo ze-amino acid

I-Tyrosine iyi-aminocarboxylic acid ebalulekile enemibandela ebandakanyeka ku-catabolism ne-anabolism, kufaka phakathi ukuhlanganiswa kwamaprotheni emisipha, i-dopamine, kanye nama-neurotransmitters. Kwenziwe nge-phenylalanine.

Indlela yokwenziwa kweTyrosine

Ifomula yobuciko be-tyrosine yi-C₉H₁₁NO₃, i-phenylalanine yi-C₉H₁₁NO₂. I-Tyrosine yakhiwa ngohlelo olulandelayo:

C₉H₁₁NO₂ + phenylalanine-4-hydroxylase => C₉H₁₁NO₃.

Imiphumela yezinto eziphilayo ze-tyrosine

I-tyrosine iwuthinta kanjani umzimba nokuthi yenziwa yiphi imisebenzi:

• isebenza njengezinto zepulasitiki zokwakhiwa kwe-melanin, i-catecholamine hormone noma i-catecholamines (i-adrenaline ne-norepinephrine, i-dopamine, i-thyroxine, i-triiodothyronine, i-L-dioxyphenalalanine), ama-neurotransmitters kanye nama-neurotransmitter;
• ubamba iqhaza ekusebenzeni kwendlala yegilo kanye nezindlala ze-adrenal;
• kuthuthukisa ukukhuthazela ngaphansi kwengcindezi, kuthuthukisa ukululama ngaphambi kwesikhathi;
• kunomphumela omuhle ekusebenzeni kwesistimu yezinzwa nemishini ye-vestibular;
• ithanda ukukhipha ubuthi emzimbeni;
• ibonisa isenzo sokucindezeleka;
• kwandisa ukuhlushwa kwengqondo;
• ubamba iqhaza ekushintshaneni kokushisa;
• kucindezela i-catabolism;
• kunciphisa izimpawu zesifo sangaphambi kokuya esikhathini.

Ukusetshenziswa kwe-tyrosine yokwehlisa isisindo

Ngenxa yekhono layo lokuthuthukisa ukusetshenziswa kwamafutha, i-L-tyrosine isetshenziswa ngesikhathi sokomiswa (ukunciphisa umzimba) ngaphansi kweso lodokotela wezemidlalo.

Kudingeka i-tyrosine engakanani ngosuku

Umthamo wansuku zonke we-tyrosine usukela ku-0.5-1.5 amagremu, kuya ngesimo se-psycho-ngokomzwelo nangokomzimba. Ukuthatha i-amino acid izinyanga ezingaphezu kwezingu-3 zilandelana akunconywa. Kungcono ukudla ngokudla ngamanzi amancane.

Ukuze uthuthukise umphumela wokwelashwa, i-tyrosine inconywa ukuthi isetshenziswe kanye ne-methionine namavithamini B6, B1 no-C.

Ukuntuleka nokwedlula kwe-tyrosine, izimpawu nemiphumela

Ukweqisa (i-hypertyrosinosis noma i-hypertyrosinia) noma ukushoda (i-hypothyrosinia noma i-hypothyrosinosis) ye-amino acid tyrosine emzimbeni kungaholela ekuphazamisekeni komzimba.

Izimpawu zokweqisa nokushoda kwe-tyrosine azicacisiwe, ezenza ukuthi ukuxilongwa kube nzima. Lapho wenza ukuxilongwa, kubalulekile ukubheka imininingwane ye-anamnestic (edluliselwe kusihlwa sesifo, imishanguzo ethathiwe, ekudleni).

Okweqile

Ukweqiwa kwe-tyrosine kungazibonakalisa njengokungalingani emsebenzini:

• izindlala ze-adrenal;
• isimiso sezinzwa esiyinhloko nesiphathelene nomngcele;
• indlala yegilo (hypothyroidism).

Ububi

Ukushoda kwe-amino acid kubonakala ngezimpawu ezilandelayo:

• umsebenzi owandisiwe ezinganeni;
• ukwehlisa umfutho wegazi (umfutho wegazi);
• ukwehla kwezinga lokushisa komzimba;
• ukuvimbela ukusebenza ngokomzimba nangokwengqondo kubantu abadala;
• ubuthakathaka bemisipha;
• ukucindezeleka;
• ukushintsha kwemizwelo;
• ukuzuza kwesisindo ngokudla okuvamile;
• imilenze engenakuphumula;
• ukulahleka kwezinwele;
• ukwanda kobuthongo;
• ukuncipha kokudla.

Ukushoda kweTyrosine kungaba ngumphumela wokushoda kokudla kwayo ngokudla noma ukwakheka okunganele kwe-phenylalanine.

I-Hypertyrosinosis ibonakala ngokwengxenye ngokukhushulwa okwandisiwe kokukhiqizwa kwe-thyroxine (Isifo samathuna):

• ukwehla okuphawulekayo kwesisindo somzimba;
• ukuphazamiseka kokulala;
• ukwanda kokuzijabulisa;
• isiyezi;
• ikhanda;
• i-tachycardia;
• izimpawu ze-dyspeptic (ukungabi nesifiso sokudla, isicanucanu, isilungulela, ukuhlanza, ukwanda kwe-asidi yejusi lesisu, i-hyperacid gastritis noma i-gastric noma i-duodenal ulcer).

Izimo

Amalungiselelo eTyrosine awanconyelwe ukusetshenziswa ne:

• ukungabekezelelani noma ukusabela okweqile kuzinto zesengezo noma isidakamizwa;
• izifo ze-thyroid gland (hyperthyroidism);
• ukugula ngengqondo (schizophrenia);
• ifa le-tyrosinemia;
• ukwelashwa nge-MAO (monoamine oxidase) inhibitors;
• Isifo sikaParkinson.

Okuqhamuka uma udla imishanguzo

Imiphumela emibi iyahlukahluka futhi ayinqunywa kuphela ngezimpawu zomuntu ngamunye, kodwa futhi nangokuhlukahluka kokuphendula kwamakhemikhali lapho i-aminocarboxylic acid ibandakanyeka khona. Mayelana nalokhu, ukuze kuvinjelwe, kunconywa ukuqala ukuthatha i-amino acid ngomthamo omncane ngaphansi kokuqondisa kukadokotela oya khona.

Imiphumela emibi kakhulu ibandakanya i-arthralgia, ikhanda elibuhlungu, isilungulela, nesicanucanu.

Ukusebenzisana

Ushintsho kumthelela wemithi we-tyrosine alufakwa ngaphandle uma lusetshenziswa kanye notshwala, ama-opiates, ama-steroids noma izengezo zemidlalo. Kulokhu, kungakuhle ukwandisa inani lezidakamizwa ezithathwe kancane kancane, ukuze, uma kunesidingo, ukukhipha inhlanganisela engathandeki.

Ukudla okune-Tyrosine

I-amino acid itholakala enyameni yezilwane ezincelisayo, izinyoni nezinhlanzi, ubhontshisi, amakinati, imikhiqizo yobisi, ubhontshisi, ukolweni, i-oatmeal, ukudla kwasolwandle, izithasiselo zokudla.

Ukudla kwezemidlalo nge-L-tyrosine

I-L-Tyrosine itholakala kumathebulethi ayi-1100 mg kanye no-400 mg, 500 mg noma ama-capsules ayi-600 mg. Imbiza epulasitiki eyi-1 iqukethe amaphilisi angama-60, noma ama-50, 60 noma ama-capsules ayi-100. I-Microcrystalline cellulose, i-aerosil neMg stearate zisetshenziswa njengezigcwalisi.

Intengo ekhemisi yamaphilisi ayi-60 ka-500 mg aphakathi kwama-ruble angama-900-1300.

Isicelo nemithamo

Imfuneko emaphakathi yansuku zonke ye-tyrosine yomuntu omdala ingama-25 mg / kg (1.75 g / ngosuku). Imithamo ingahluka ngokuya ngenhloso yokusebenzisa into (ekhethwe ngudokotela oya khona).

Kunconywa ukunciphisa imikhiqizo nge-tyrosine ku-apula noma ijusi le-orange.

Bukela ividiyo: Metabolism of phenylalanine and tyrosine (Julayi 2025).