Ngo-2010, i-American Journal of Clinical Nutrition yashicilela imiphumela yokuhlolwa okungahleliwe kwemitholampilo yezidakamizwa eziningana ezine-carnitine njengesithako esisebenzayo. Ezidakamizweni eziyi-12, ziyi-5 kuphela ezakhombisa umphumela wokwelapha.Omunye wemithi esebenza kahle kakhulu kwakunguCarnicetin.
Amalungiselelo asekelwe ku-Carnitine asetshenziselwa umuthi ukwelapha izifo ezizalwe nazo ezihambisana nokuhlangana okwanele okungapheli kwento, izinkinga zezinzwa nezinye izifo.
Le nhlanganisela isetshenziswa kakhulu kwezemidlalo ngenxa yethonya layo lokuhleba emafutheni omzimba. Ngaphezu kwalokho, i-carnitine isheshisa ukulungiswa kwamaseli emisipha, yandisa ukukhuthazela futhi ithuthukise kakhulu ukusebenza kwengqondo engqondweni.
Ulwazi oluvamile
I-Carnitine iyinhlanganisela eyenziwe yi-parenchyma yezinso nesibindi. Le nto idlala indima ebalulekile ezinqubweni zomzimba zamakhemikhali - iqinisekisa ukuthuthwa kanye namachibi e-lipids kuma-laboratories wamandla wamaseli - i-mitochondria, isekela ukwakheka kwamangqamuzana ezinzwa, inciphisa i-apoptosis yamaseli angaphambi kwesikhathi (okungukuthi, ukufa okuhleliwe) futhi ibambe iqhaza ezinhlelweni zokukhula kanye nokukhula komzimba. Kunezinhlobo ezimbili zokwakheka kwenhlanganisela - D no-L, kuyilapho kuphela i-L-carnitine inomsebenzi wezinto eziphilayo.
Ngokokuqala ngqa, le nto yahlukaniswa nezicubu zemisipha ososayensi baseRussia ekuqaleni kwekhulu le-19. Kamuva, ochwepheshe bathola ukuthi ukuntuleka kokuxhumeka kuholela ekwakhekeni kwezifo ezimbi zezitho zangaphakathi ezinezidingo zamandla aphezulu - inhliziyo, ubuchopho, izinso, isibindi.
Khipha ifomu nokwakheka
Umuthi itholakala ngesimo amaphilisi e inani izingcezu 60 iphakethe elilodwa. Isithako esisebenzayo yisimo se-L se-carnitine, okuyi-acetylcarnitine. Ukulungiselela kuqukethe izingxenye ezengeziwe - i-magnesium stearate, i-microcrystalline cellulose, i-Aerosil A-300.
Izici zemithi
I-L-form ye-carnitine inethonya le-catabolic kuma-fatty acids, okungukuthi, ibamba iqhaza kwi-lipid peroxidation e-mitochondria. Ngenxa yokusabela kwamakhemikhali ezinto eziphilayo, amandla akhishwa ngendlela yama-molecule e-ATP. Futhi, into igcina ibhalansi ye-acetyl-CoA ngaphakathi kweseli nasesikhala esiphakathi kwamaseli. Lo mphumela unomphumela we-neuroprotective ngokwandisa ukuhlanganiswa kwe-phospholipids - izingxenye zezingqamuzana zeseli zezinzwa.
I-Carnicetine isheshisa ukudluliswa kwemithambo ye-electrochemical kuma-synapses, nawo athuthukise ukusebenza kobuchopho. Ukweqiwa okwelashwa komuthi kuvimbela ukuthuthukiswa kokulimala kweschemic kumaseli wesistimu yezinzwa. Ikhompiyutha inamandla okuzivuselela okuhlukumezeka ngomshini nezinye izinhlobo zokulimala kwezinzwa okulingene.
I-Carnitine, eyingxenye yomuthi, ithuthukisa inkumbulo nokusebenza kobuchopho, yandisa ukuqapha nokufunda. Isidakamizwa sikhombise umphumela obonakalayo njengengxenye yokwelashwa okuyinkimbinkimbi kweziguli ezinesifo i-Alzheimer's. Isidakamizwa sinenzuzo yokusebenza kwengqondo okukhulu, ngakho-ke, kunqunyelwe ukugcina ukusebenza kwe-neurons ngesikhathi sokulungiselela izivivinyo.
Kuyasebenza futhi lapho kunikezwa abantu asebekhulile abanokuwohloka komqondo.
Isidakamizwa sithuthukisa uketshezi nomphumela we-endo native serotonin futhi sinomphumela wokulwa ne-antioxidant. Lo mphumela ukuvumela ukuthi ugcine ubuqotho bamaseli nolwelwesi lwawo.
I-Acetylcarnitine isheshisa inqubo yokwehlisa isisindo ngokuvuselela ukusabela kwe-lipid ne-carbohydrate metabolism. Ukusetshenziswa kwesidakamizwa ngesikhathi somsebenzi omkhulu womzimba kukhulisa ukukhuthazela ngenxa yokwanda kokwakhiwa kwama-molecule we-ATP e-mitochondria.
Ngenxa yokufana kwesakhiwo se-carnitine ne-mediator acetylcholine, lesi sidakamizwa sibangela umphumela olinganiselayo we-cholinomimetic ngendlela yokwehla okuncane kokushaya kwenhliziyo, ukwanda kokuqina kwemisipha ebushelelezi yesibeletho, isinye, nokwehla kwengcindezi ye-intraocular.
Izinkomba
Isidakamizwa sinqunyelwe:
- Isifo i-Alzheimer's - isifo esibonakala ngokuwohloka okusheshayo kwama-neuron ebuchosheni, ngemisebenzi yokuphazamiseka kwengqondo, i-neurological pathologies, amnesia nokunye ukubonakaliswa;
- i-polyneuropathies - ukulimala kwezinzwa zomzimba ezibhekene nesizinda sikashukela, ukuphuza ngokweqile nezinye izimo zokugula;
- ukuwohloka komqondo kubantu asebekhulile, okuthuthuka ngenxa yezinguquko ze-atherosclerotic ezitsheni zobuchopho.
Kwezemidlalo, iKarnitsetin isetshenziselwa ukuvuselelwa okusheshayo kwezicubu zemisipha nezinzwa uma kwenzeka kwenziwa i-microtraumatization ngemuva kokuzikhandla okukhulu komzimba. Futhi, lesi sidakamizwa sandisa ukukhiqizwa kwamandla yi-mitochondria. Lo mphumela unikeza ukumbozwa okugcwele kwezindleko zamandla hhayi kuphela ngesikhathi sokuqeqeshwa, kepha nangesikhathi sokusebenza kwengqondo.
IKarnitsetin isetshenziswa ngabasubathi ababandakanyeka emidlalweni enzima yokukhumbula ngekhanda okukhiqizayo nokwazi ukunyakaza.
Umphumela we-antioxidant ukuvumela ukuthi unciphise ama-metabolites nobuthi, uvimbele ukuguga ngaphambi kwesikhathi kwamaseli. I-Carnicetin isetshenziselwa ukwehlisa isisindo, njengoba into esebenzayo ikhuthaza ukuphuma edepho nasekugayweni ngokushesha kwe-lipids. Le mpahla isetshenziswa ngabakhi bomzimba ngaphambi kokudlala ukunikeza ukukhululeka komzimba.
Izimo
Umuthi is contraindicated uma ukusabela iguliswa noma ukungabekezelelani izingxenye. Uma kuvela izimpawu ezingathandeki, kufanele uyeke ukuthatha imithi bese uthintana nodokotela.
Izifundo zomtholampilo zokusebenza nokuphepha komuthi zenziwa emaqenjini okugxila kuwo, afaka abantu abaneminyaka engaphezu kwengu-18 ubudala, ngakho-ke, ukusetshenziswa komuthi ngabancane akunconywa.
Izimo ezihlobene - ukukhubazeka kwesisu noma isilonda esiswini, ukwehluleka kwezinso ngokuncipha okuthe xaxa kumthamo wokuhlunga we-apparatus ye-glomerular, umsebenzi we-thyroid onganele.
Ngenxa yomphumela we-atherogenic, akunconywa ukuthatha iCarnicetin yeziguli ezinesifo senhliziyo, ukubola kwe-myocardial infompion, ukwehluleka kwenhliziyo, nomfutho wegazi ophakeme.
Uma unezinhlungu zemisipha, imithi ingase isibhebhethekise uphawu.
Indlela yokuphatha kanye nomthamo
I-capsule ilawulwa ngomlomo. Umthamo onconyiwe ngamaphilisi ayi-6-12 ngosuku.
Kubasubathi, kunezinhlobo ezikhethekile zokudla izidakamizwa - kunconywa ukusebenzisa lesi sidakamizwa izinyanga eziyi-1-3 ngesikhathi sokuqeqeshwa, ukulungiselela imincintiswano nokusebenza.
Umthamo wansuku zonke ungama-600-2000 mg, ngokuya ngobulili, ubudala kanye nezici zomzimba ngamunye.
Umphumela omkhulu ubonwa ngokusetshenziswa okuhlanganisiwe kweCarnicetin enezithako zamaprotheni.
Kunconywa ukuthatha lesi sidakamizwa imizuzu engama-30-60 ngaphambi kokuqala kokuzivocavoca
Okuqhamuka uma udla imishanguzo
Imiphumela emibi ebikiwe yayihlotshaniswa nokusabela okweqile noma ukungabekezelelani komuntu ngamunye ezingxenyeni zomuthi. Isicanucanu, ukuhlanza nokushiswa yinhliziyo kungenzeka. Ukubonakaliswa okungathandeki kuyanyamalala ngemuva kokuphela komuthi.
Ucwaningo lwaseCleveland Clinic lwango-2011 luxhumanise ukusetshenziswa kwe-carnitine nengozi eyengeziwe ye-atherosclerosis. Le nhlanganisela isetshenziswa ezinye izinhlobo zamagciwane angenele njenge-substrate yokwenziwa kwento ethile enesikhathi esifushane sokuphila - i-trimethylamine, ephinde iguqulwe ibe yi-trimethylamine oxide - esinye sezici ezinamandla kakhulu ze-atherogenic.
Ukweqisa ngokweqile
Amacala okweqisa izidakamizwa awaziwa, noma kunjalo, kunobufakazi bokuthi ukuqwasha kungaqala lapho usebenzisa lesi sidakamizwa ngobuningi.
Ukwedlula umthamo omkhulu ovunyelwe ezimweni ezingavamile kubonakaliswa ubuhlungu be-spastic esifundeni se-epigastric, ukuphazamiseka kwesitulo, isicanucanu, ukuhlanza nokubukeka komoya onukayo.
Imiyalelo ekhethekile
Ukuphathwa ngasikhathi sinye kweCarnicetin neziphuzo ezidakayo akukhuthazwa, ngoba i-ethyl alcohol inciphisa ukusebenza komuthi.
Ukusebenzisana kwezidakamizwa
Ukusebenzisana kweCarnicetin nezinye izidakamizwa akukaziwa.
Ama-analogs
Ama-analogue eKarnitetin afaka:
- I-Carnitex;
- I-Acetylcarnitine.
Imigomo nemibandela yesitoreji
Kunconywa ukugcina umuthi lapho izingane zingafinyeleleki khona. Gwema ilanga eliqondile. Izinga lokushisa eliphelele lesitoreji lisuka kuma-degree angama-15 kuye kwangama-25. Impilo yeshalofu ingunyaka owodwa.
Imibandela yokukhishwa kwamakhemisi
Ngo-2018, lesi sidakamizwa ngumuthi kadokotela.
Intengo emakhemisi
Izindleko ezijwayelekile zephakethe leKarnitetin ezikhemisi ziyahlukahluka kusuka kuma-ruble angama-510 kuye kwangama-580. Akunconyiwe ukuthenga umuthi ngesandla, ngokusho kwezikhangiso ku-Avito, njll. Thenga kuphela kubasabalalisi abagunyaziwe.
