ICoenzyme Q10 yinto ekhiqizwa amaseli womuntu futhi isekela imisebenzi yayo ebalulekile. Ukuntuleka kwayo kugcwele ukuthuthukiswa kwezifo ezimbi. Kulokhu, ukugcwaliswa komzimba okunomsoco ovela ngaphandle, kusuka kwizithasiselo ezisebenza ngokwemvelo nemikhiqizo yokudla, kuyasiza.
Ukwelashwa ngalezi zindlela kukhulisa ukukhuthazela, kubambezela inqubo yokubola nokuguga, kusiza ekulweni nengculaza, izimila zomzimba, isifo senhliziyo nezinye izifo eziningi.
Yini i-ubiquinone nokuthi yiziphi izakhiwo zayo
I-Ubiquinone iyindlela ene-oxidized ye-coenzyme etholakala e-mitochondria, okuyizikhungo zokuphefumula namandla eseli ngalinye lomzimba. Ikhuthaza ukukhiqizwa kwamandla kuzo ngendlela ye-ATP, ibamba iqhaza ochungechungeni lwezokuthutha lwe-electron ezingeni lamaselula.
Ngokuvamile, i-ubiquinone yenza lezi zenzo ezilandelayo:
- i-antioxidant - inciphisa ama-radicals mahhala kanye ne-cholesterol eyingozi, inciphisa inqubo yokuguga;
- i-antihypoxic - umphumela ukuthuthukisa ukusakazwa komoya-mpilo emzimbeni;
- i-angioprotective - ukuqinisa nokubuyiselwa kwezindonga ze-vascular, ukujwayelekile kokugeleza kwegazi;
- ukuvuselela - ukubuyiselwa kwezingqamuzana zamaseli nokusheshisa kokuphulukiswa kokulimala;
- i-immunomodulatory - ukulawulwa kokusebenza kwamasosha omzimba.
Umlando wokusetshenziswa kwezakhi uhlehlela emuva ku-1955-1957, lapho yafundwa okokuqala ngokuzimisela kwesakhiwo sayo samakhemikhali.
Leli gama lanikezwa ubiquinone ngenxa yemvelo etholakala kuyo yonke indawo, okungukuthi, ikuyo yonke indawo.
Ngesikhathi esifanayo, kwaqala ukuthuthukiswa kwezidakamizwa ezisekelwe kuyo, ezazisetshenziswa ngo-1965 ekwelapheni izifo zenhliziyo.
I-Ubiquinone isebenza kahle nezinye izinto ezithinta i-mitochondria. Ubhekene nokukhiqizwa kwamandla, ekusetshenzisweni kwe-carnitine ne-thioctic acid okubandakanyekayo, futhi i-creatine ikhuthaza ukukhishwa kwayo (umthombo - i-NCBI - Isikhungo Sikazwelonke Semininingwane Ye-Biotechnology).
Mayelana nalokhu, i-enzyme isetshenziselwa izinhloso ezilandelayo:
- ukuzinza kohlelo lwe-cardiovascular and normalization of blood pressure;
- ukwenza ngcono izakhiwo ezinwebekayo zezindonga zemithambo nokuziqinisa;
- ukunciphisa ubukhulu bezingqimba ze-cholesterol nezimpawu ze-atherosclerosis;
- ukuvimbela nokubambezela inkambo yesifo sika-Parkinson noma i-Alzheimer's;
- ukuhlela ukusebenzisa noma imithwalo yesikhathi eside;
- ukwelashwa kwesifo sezinsini;
- ukuvimbela izifo zomdlavuza;
- ukusekelwa kombuso uma kwenzeka izifo zomzimba zivikelekile;
- ukunciphisa isikhathi sokuvuselelwa ngemuva kwezifo ezinzima kanye nokungenelela kokuhlinzwa.
Indlela yokusebenza
Indima ye-coenzyme Q10 ukuqala uchungechunge lokuhlangana kwamakhemikhali okusheshisa ukwehlukaniswa kokudla kube ngamandla.
Incazelo yendlela yokusebenza iqala ngokuhlanganiswa kwe-ubiquinone, eyakhiwa ngamaseli kusuka ku-mevalonic acid, imikhiqizo ye-metabolic ye-phenylalanine ne-tyrosine.
Ibamba iqhaza kuzinqubo zezokuthutha nezamandla, ithwebula ama-proton nama-electron avela kwizakhiwo I no-II zochungechunge lokuphefumula. Ngakho-ke yehliselwa ekubeni yi-ubiquinol, into esebenzayo ngokwengeziwe ngokutholakala kokutholakala kokutholakala kokutholakala okuningana namandla okungena.
Isici esivelisayo sidlulisela ama-electron amabili kwisakhiwo se-III sokhiye wokuphefumula, abambe iqhaza ekwakhiweni kwe-adenosine triphosphoric acid (ATP) kulwelwesi lwe-mitochondrial. Isebenza ngqo kuma-radicals wamahhala, inomphumela we-antioxidant kumaseli abhubhisa izinto.
Umthelela esikhathini sokuphila
Amandla okuhlanganisa i-ubiquinone aphakeme kakhulu esemncane futhi uma umzimba unenani elanele lamavithamini A, C, iqembu B kanye ne-amino acid tyrosine enephunga elimnandi.
Eminyakeni edlule, inani lalo lehla ngokushesha, futhi ingozi yezifo iyanda, phakathi kwakho okulandelayo okuvame kakhulu:
- i-fibromyalgia - isifo esingelapheki semisipha;
- izifo zenhliziyo nemithambo yegazi kanye nezinkinga zazo;
- ukuphazamiseka kofuzo kukaPrader-Willi ezinganeni ezisanda kuzalwa;
- i-parkinsonism, ihambisana nokuhamba kancane, ukungazinzi kokuhamba nokuthuthumela kwezandla;
- Isifo sikaHuntington;
- i-amyotrophic lateral sclerosis;
- ukukhuluphala;
- isifo sikashukela;
- ukungazali kwabesilisa;
- ukungasebenzi kahle kwesimiso somzimba sokuzivikela ezifweni, okungaguqulwa kube imikhuhlane njalo, izifo ezizimele, ama-neoplasms amabi;
- ukudana, i-migraines ejwayelekile, njll.
Ukwengezwa kweCoenzyme Q kungabekwa ukuvimbela lezo zifo noma ukwelapha izinkinga ezikhona.
Ngaphandle kokuthi ayikweluli isikhathi sokuphila, umsoco unikeza umphumela omuhle wokulwa nokuguga ekugcineni impilo yomuntu.
Umphumela emzimbeni
Njenge-coenzyme encibilikiswa ngamafutha, i-coenzyme ithathwa kalula yizicubu nezitho zomzimba lapho ingena ivela ngaphandle. Ngokuya ngemisebenzi, iyafana nama-vitamin compounds, okuholela ekunikezelweni kwegama elithi pseudovitamin noma i-vitamin Q10 kuyo.
Isamba esiphezulu sitholakala ezithweni ezithwala izindleko zamandla eziphakeme kakhulu, njengenhliziyo, izinso nesibindi.
Ukufakwa okwengeziwe kwesakhi kuqala izinqubo ezilandelayo:
- kwandisa ukukhuthazela kubasubathi;
- ithuthukisa umsebenzi womzimba ekugugeni;
- kunciphisa ukulahleka kwe-dopamine, kokugcina imisebenzi ye-reflex kwisifo sikaParkinson;
- kuqinisa izicubu futhi kuvimbele imiphumela elimazayo yemisebe ye-ultraviolet esikhunjeni, ithuthukise ukuqina kwayo nokuzivuselela;
- kunciphisa ukulimala okwenziwe emisipheni yenhliziyo futhi kwandise impilo yezinye izitho;
- ukunciphisa imithambo yegazi, kwehlisa umfutho wegazi futhi kwenyuse ukugeleza kwegazi uma kuthikamezeka;
- kwandisa isilinganiso se-insulin ne-proinsulin, kunciphisa inani le-glycohemoglobin egazini, kunciphise ubungozi bezinkinga zesifo sikashukela;
- kwandisa ukusebenza kwamaprotheni ezicutshini zemisipha, kunciphisa ukukhathala nokukhulisa ukukhuthazela ngesikhathi sokuqina kwabo okukhulu (umthombo - i-NCBI - Isikhungo Sikazwelonke Semininingwane Ye-Biotechnology).
ICoenzyme kwezemidlalo
ICoenzyme Q10, etholakala ngesengezo, ivame ukusetshenziswa ngabasubathi ukwenza ngcono ikhwalithi nobude bokuqeqeshwa, kanye nokuqeda imiphumela yokusebenza komzimba. Futhi, i-Q10 ingumthombo omuhle wamandla wokungezelela wabasubathi.
Isengezo sokudla sinciphisa ukulimala kwezicubu ezinobuthi okubangelwa ukungabikho komoya-mpilo kuzo.
Le mpahla ibaluleke kakhulu lapho kwenziwa uqeqesho lwe-anaerobic, ukukhuphukela ezindaweni eziphakeme kakhulu.
Umthamo wansuku zonke womuthi yi-90-120 mg. Ngezinhloso zokwakha umzimba, kuhle ukusebenzisa cishe i-100 mg ngokuhlanganiswa namavithamini C no-E. Lokhu kuzosebenza njengomthombo owengeziwe wamandla.
Izinkomba zokusetshenziswa
Izinkomba zokusetshenziswa kwe-ubiquinone kungaba:
- ukucindezeleka ngokweqile ngokomzimba noma kwengqondo;
- izimo ezicindezelayo, ingcindezi yengqondo;
- umfutho wegazi ophakeme noma ophansi;
- ukwelashwa ngamakhemikhali nokuhlinzwa;
- izifo ezithathelwanayo ezinciphisa ukuzivikela komzimba;
- ukungabi namandla e-HIV kanye ne-AIDS;
- ubungozi be-post-infarction syndrome kanye nokwanda okukhulu ngemuva kokushaywa unhlangothi;
- ukwandisa amazinga e-cholesterol egazini;
- ukuvimbela ukungabi nenzalo emadodeni;
- izifo zokuphefumula;
- izinsini zokopha, isifo se-periodontal, i-stomatitis;
- isifo sikashukela;
- i-arrhythmia, i-angina pectoris nezinye izinkinga emkhakheni we-cardiology.
Isikhathi yokwemukelwa kanye umthamo isethwe ngamunye ngosizo ongoti.
Izimo
Ukuphikisana nokusetshenziswa kwe-coenzyme yile:
- inkinga ye-peptic ulcer;
- i-glomerulonephritis ebhebhethekisile;
- ukwehla kokushaya kwenhliziyo (ukushaya okungaphansi kwama-50 ngomzuzu);
- ukuzwela komuntu ngamunye ezingxenyeni ezithile;
- ukukhulelwa, ukuncelisa kanye nobudala obufinyelela eminyakeni eyi-18.
Indawo eyingozi ibandakanya neziguli ezinezifo zomdlavuza nezenhliziyo. Uma kutholakala, isengezo kufanele sixoxwe nodokotela wakho.
Amafomu wokukhishwa nendlela yokusebenzisa
I-Ubiquinone ikhiqizwa ngendlela yezithako zokudla ezinezinhlobo ezahlukahlukene zokukhishwa kanye nama-analog amaningi avela kubakhiqizi abahlukahlukene:
- i-gelatin capsules enoketshezi oluphakathi, olumuncwa kahle ngumzimba (iDoppelgertsaktiv, Forte, Omeganol, Kaneka);
- amaphilisi ane-potassium, i-magnesium nezinye izinto (iCoenzyme Q10, iCapilar cardio);
- UVitamin Gummies (osuka eKirkman)
- amaconsi okwengeza iziphuzo ezingcono ekudleni nokudla okunamafutha (Kudesan);
- Isixazululo somjovo we-intramuscular (Coenzyme Compositum).
Ngokuvamile, umzimba udinga ama-50 kuya ku-200 mg we-coenzyme ngosuku lapho kungekho zifo ezimbi kakhulu. Indlela yesicelo - kanye ngosuku, nokudla, njengoba kubhekiswa ezintweni ezincibilikayo ezinamafutha.
Ngezinhloso zokwelapha, umthamo ukwanda kuphela nguchwepheshe ngokuhlolwa kanye nomlando ophelele wokugula. Isibonelo, ngesifo sikaParkinson, izidingo zansuku zonke zizokhula kaningi.
Ubuhle nobubi
Phakathi kwezici ezinhle ze-Q10:
- ukuthuthuka okubonakalayo kwesimo seziguli ezinezifo zenhliziyo nemithambo yegazi;
- ithuba lokusebenzisa ukuvimbela futhi ngaphandle kwencwadi kadokotela;
- umphumela oyinkimbinkimbi kuzo zonke izinhlelo zomzimba;
- ukusheshisa kokuvuselelwa kwangemva kokuhlinzwa;
- kunciphisa ukukhula komdlavuza;
- ukukhuthazela okwandisiwe nokunciphisa ukukhathala;
- ukuphepha kokusetshenziswa uma kulandelwa izincomo.
Imiphumela emibi ibonakala kuphela uma imiyalelo ingalandelwa.
Isidakamizwa asinamphumela onobuthi emzimbeni, njengesengezo semvelo.
Kodwa kungcono ukumuncwa ngokudla kwansuku zonke okungekho ngaphezu kwama-500 mg ekwelashweni okuyinkimbinkimbi kwesifo. Ukwedlula umthamo kuholela ekugayeni ukudla, kepha akunayo eminye imiphumela emibi, noma ngabe kusetshenziswa isikhathi eside. Kwezinye izimo, imithamo eyeqile ingasheshisa inqubo yokuguga, ukuphazamiseka kokulala noma ukuqubuka kwesikhumba.
Ukuvimbela
Ngokwemiyalelo, i-coenzyme iyathathwa ukuvimbela nokubambezela inkambo yezifo eziningi ezimbi, njengomdlavuza, isifo senhliziyo, isifo sohlangothi. Ngaphezu kwalokho, kuyasebenza ekuthuthukiseni isimo nasekugcineni ithoni yomzimba jikelele.
Isidingo sesengezo sokudla kungenxa yokwehla kokukhiqizwa kwe-enzyme ngobudala ngemuva kweminyaka engama-20.
Ngaphansi kokuqondisa kukadokotela ofanelekayo, izithako zokudla zingasetshenziswa ngokuqhubekayo, uma ingekho imiphumela emibi noma ukuphikiswa.
Ucwaningo Lwakamuva
Ngokuya kocwaningo lwesayensi, olwenziwa ekuqaleni kumagundane, kwembulwa ubudlelwane obuphakathi kwezinga lama-coenzymes nenani nokwakheka kokudla. Uma inani lekhalori lilinganiselwe, khona-ke emisipheni yamathambo nezinso inani le-Q9 ne-Q10 liyanda, futhi yi-Q9 kuphela eyehla ezicutshini zenhliziyo.
Ezimweni zesimanje e-Italy, kwenziwa ukuhlolwa phakathi kweziguli ezinezifo zenhliziyo. Ezifundweni ezingama-2 500, ezinye zeziguli zithathe isengezo sihlanganiswe nezinye izidakamizwa zelashwa oluyinhloko. Ngenxa yalokho, ukuthuthukiswa akubonwa kuphela enhlalakahleni ejwayelekile, kepha futhi esimweni sesikhumba nezinwele, nezinkinga zokulala zanyamalala. Abantu baqaphele ukwanda kwethoni nokusebenza, ukunyamalala kokuphefumula okufushane nokunye ukubonakaliswa okungathandeki.
