I-Riboxin: imiyalo yokusetshenziswa ekwelashweni, ukwakha umzimba nakwezemidlalo * Isiphambano

I-Riboxin yisidakamizwa esithuthukisa ukuthinteka kwenhliziyo, silungise isigqi sayo, sinciphise ukuncishwa komoya-mpilo kwezicubu futhi silawule imetabolism yomzimba.

Ngamafuphi, ingumthombo wamandla wemikhumbi ye-myocardium nemithambo yegazi. Ngokufanayo, lesi sidakamizwa sivimbela i-ischemia yezinso ngesikhathi sokuhlinzwa, sibamba iqhaza ku-glucose metabolism futhi sithatha imisebenzi ye-ATP lapho ingekho emzimbeni. I-Adenosine triphosphate ikhona kuwo wonke amaseli, kepha ngobudala noma ngezifo, inani lalo liyancipha, elidinga umthombo owengeziwe wamandla avela ngaphandle.

Ukusetshenziswa kweRiboxin kwezemidlalo kufanelekile, ngoba ukuvivinya umzimba kudinga ukukhuthazela okwandayo, futhi lo muthi uba ngumthombo wamandla owengeziwe.

Amafomu wokwakhiwa nokukhululwa

I-Riboxin iyatholakala kumathebulethi nakuma-ampoules okusetshenziswa ngomlomo nangomjovo. Kususelwa ku-inosine, isikhuthazi esishukumisayo esakha amandla emzimbeni. Ngaphezu kwalokho, isitashi, i-methylcellulose, i-sucrose nezinye izinto ze-cachet zikhona njengezinto ezingeziwe kunguqulo yetafula. Isidakamizwa singaphansi kohlu B, okungukuthi, sikhishwa kuphela ngemithi kadokotela.

Njengomthombo wamandla, iRiboxin iyathakazelisa kubadlali abathi, ngesikhathi sokuqeqeshwa, bazinikeze umsebenzi owandayo womzimba. Iqiniso ngukuthi ezingeni lamangqamuzana kuyisisekelo se-ATP (adenosine triphosphate) - isisekelo sempilo yomzimba. Umsebenzi oyinhloko wale asidi, ekhiqizwa emzimbeni uwedwa, ukugcina imisipha yenhliziyo isesimweni esifanele futhi iqinisekise ukungabikho kwe-hypoxia ezicutshini.

I-Riboxin iba yinto eyengeziwe evimba ukuntuleka kwe-ATP ezimweni ezahlukahlukene. Isidakamizwa sinesibopho sokulungiswa kwe-arrhythmias, sisheshisa izinqubo ze-anabolic, sandisa imithambo yegazi, evuselela amandla okuqina kwenhliziyo futhi ithuthukise ukugeleza kwegazi.

Ekusebenzeni, isiguli sithola ukuqhuma kwamandla, izinhlungu zesifuba, imigraines, ubuthakathaka, ukukhathala kuyanyamalala, ukuphefumula cishe kuyayeka ukumkhathaza.

I-Riboxin igcinwa endaweni emnyama lapho izingane zingafinyeleleki khona, ezingeni lokushisa elingu-0 kuye +25 degrees, iminyaka emihlanu.

Isandulela ku-ATP

I-Riboxin kwesinye isikhathi ibizwa ngevithamini yenhliziyo. Kepha lokhu akuyona incazelo enembile ngokuphelele. Ngempela, ngaphandle kwengxenye yayo eyinhloko - ama-inosine - amaseli awakwazi ukufaka amavithamini noma ama-microelements. I-Hypoxia ivela kuzo, futhi inhliziyo ingama ngokuphelele. Njengoba i-inosine iyi-nucleoside eyingxenye yelungu ngalinye leseli, ukushoda kwayo kubangela ukungasebenzi kahle kwezitho nezicubu ezahlukahlukene. Abokuqala ukuhlupheka:

Uhlelo lwe-cardiovascular, lapho i-ischemia, i-atherosclerosis, i-myocardial dystrophy iqhubekela phambili ngokumelene ne-hypoxia yangemuva.
Indlala yesibindi, ye-oksijini okuholela ekuvukeleni nomphumela we-cirrhosis. Ama-hepatocyte ahlupheka, indlala ilahlekelwa ngumsebenzi njengesihlungi semvelo.
Amehlo, okungukuthi: i-optic nerve kanye nemisipha ye-ocular apparatus. Ubukhali bokubukwa nokuqhathanisa kulahlekile.
Izinso nokwakheka kwe-uroporphyria - ukuphazamiseka kwemetabolism ezingeni lendawo.
Isisu - i-hypoxic toxicosis yephula ubuqotho be-mucous membrane nokwakheka kokuguguleka.

I-Riboxin, ingena emzimbeni, ibeka konke endaweni. Njengomthombo we-ATP, yehlisa umfutho wegazi ngokujwayela udonga lwemithambo, kepha kuvela ukuthi iyingozi ezigulini ezine-hypotensive. Kuvusa amasosha omzimba, kusize ukumelana nokwelashwa ngemisebe. Izakhiwo ezifanayo zomuthi zisetshenziselwa ezemidlalo ukumelana nokuqina kwengcindezi ekuqeqesheni nasekuncintisaneni, ukuvimbela imisipha kanye ne-ligament sprains.

Imiyalo yokusetshenziswa

I-Riboxin ithathwa ngokuya ngemithetho ethile.

Uma ijojowe, futhi lokhu kungukulethwa okuhle kakhulu kwe-inosine emzimbeni, lapho-ke kukhethwa imijovo yemisipha noma yokuphathwa kwemithambo: ukuvuza noma ukusakaza. Umjovo wokuqala ngu-200 mg kanye ngosuku. Kuncike ngaphandle kwemiphumela emibi, umthamo uphindwe kabili. Inkambo yizinsuku eziyi-10. Nge-dropper, umuthi ujovwa kancane ukukhipha ukushaya kwenhliziyo: awekho ngaphezu kwamaconsi angama-50 ngomzuzu.
Amaphilisi noma amaphilisi asetshenziswa kusukela eminyakeni eyishumi nambili. Umthamo wokuqala uyithebhulethi (i-capsule) kathathu ngosuku. Ngokubekezelelana okuhle, umthamo uyanda: okokuqala, amaphilisi amabili kathathu ngosuku, bese kuba amane. Izinkinga zomzimba zishintsha uhlelo: ithebhulethi izikhathi ezine ngosuku, inyanga noma ezintathu. Ukwamukelwa kwenzeka emizuzwini engu-30 ngaphambi kokudla, ama-capsules ahlanzwa ngamanzi alula.
Kubadlali, uhlobo oluhle kakhulu ukuthatha iphilisi emahoreni ambalwa ngaphambi kokuqeqeshwa. Inkambo ayikho ngaphezu kwezinyanga ezintathu ngekhefu lezinsuku ezingama-30. Umphumela oseceleni weRiboxin ukuqoqwa kwesisindo semisipha.

Izimo zokwamukelwa

I-plus enkulu yeRiboxin ubuncane bokuphikisana. Kepha yilezi:

Ukuzwela komzimba, i-urticaria. Lapho umuthi ukhanseliwe, konke kuyanyamalala.

Ukwanda kwe-gout ngokuphathwa ngomlomo isikhathi eside. I-Purine, eyandulela i-Riboxin, ibandakanyekile ekuguqulweni kwe-uric acid. Ukuba khona kwayo isikhathi eside emzimbeni kuvusa ukuhlaselwa yi-gouty.
I-CKD.
I-Terminal leukemia.
Ukungabekezelelani komuntu ngamunye.
Amaviki okubeletha kanye nesikhathi sokuncelisa ibele kudinga ukuncishiswa kokudla izidakamizwa noma ukuqedwa ngokuphelele.

Endabeni yokwelashwa ngamakhemikhali, kukhona ingozi ye-metabolic hyperuricemia okuholela ekutheni i-gout. Ngakho-ke, oncologists unikeze izidakamizwa ngokunakekela okukhulu futhi ngaphansi kweso.

Ukukhulelwa ngaphambi kwamasonto okubeletha akuwona umkhawulo ekuthatheni iRiboxin. Ngokuphambene nalokho, usindisa omama abakhulelwe ezinkingeni eziningi zenhliziyo. Ubuye aqinisekise ukuqhubeka noma ukuqala kwe-gastritis, i-pathology yohlelo lwe-biliary. Isici somuthi umphumela waso omuhle kumbungu, ukuvimbela i-hypoxia yawo. Kodwa i-Riboxin inqunywe udokotela kuphela, ngemithamo ehambelana nesimo sikamama nese-fetus.

Ukwelashwa kwezifo zenhliziyo

Imisipha yenhliziyo ihlala ingaphansi kwengcindezi ehambisana nokuhlinzekwa kokudla okunomsoco nokunikezwa komoya-mpilo ezicutshini. Ngokukhula, iyaphela, okusho ukuthi, iya ngokuya ngokuxhaswa okwengeziwe kwamandla. Ihlinzekwa yi-Riboxin, esebenza njenge-cardioprotector. Iphazamisa uchungechunge lwezinqubo ezingezinhle ezibangelwa imisipha ischemia, evikela amaseli we-myocardium.

Ngeshwa, indlela esebenza ngayo ayikaze ifundwe kahle. Kepha kuyaziwa ngokuthembekile ukuthi, njengoba isuselwa ku-purine futhi eyandulela i-ATP, ikhombisa izimfanelo ze-anabolic. Ngosizo lwayo, i-anaerobic glycolysis iyasebenza, okungukuthi, ukukhiqizwa kwamandla we-anoxic kusetshenziswa i-glucose. Lokhu kunciphisa ukugxila kwayo ku-myocardium futhi kuvumela i-Riboxin ukuthi ivuselele ukuhlanganiswa kwama-nucleotide namaprotheni ngaphansi kwezimo ze-ischemic, yenza umsebenzi we-agent ye-cardioprotective.

Le yindlela amandla we-Riboxin abonakala ngayo. Lo mphumela womuthi awusetshenziswanga kuphela ekwelapheni i-myocardial ischemia, kodwa futhi nomfutho wegazi ophezulu, i-arrhythmia.

Ngomfutho wegazi ophezulu

Endabeni yengcindezi ephezulu yegazi, i-Riboxin ithinta ama-receptors amaseli, ibuyise ukusebenza kwawo. Lokhu kusebenza ikakhulukazi ezigabeni zokuqala zesifo. Ngaxeshanye, lo muthi ukuncibilika uqweqwe cholesterol, okuyinto ulungisa umsebenzi imithambo yegazi futhi ubuyisela umzimba. Ngokuhlanganiswa ne-Enapril, i-Renitek, i-Curantil, i-Delix, i-Enalzid nezinye izidakamizwa ze-hypotonic, ezikhethwa udokotela, lokhu kunikeza umphumela omuhle. Kunokwehla okuqhubekayo nokuphikelelayo komfutho wegazi.

Kodwa-ke, ukusebenzisa i-Riboxin ngokuhambisana nezinye izidakamizwa, kufanele kukhunjulwe ukuthi ayihlanganisiwe nemithi ethile, futhi uma uphuzo oludakayo ngesikhathi sokwelashwa, lungaholela enkingeni yomfutho wegazi ophakeme noma ekukhuleni kwesifo senhliziyo.

Nge-arrhythmia

Ukwephula isigqi senhliziyo emtholampilo kubonakaliswa ushintsho ekushayeni kwenhliziyo kolunye uhlangothi, isiyezi, iphika. Njengomthetho, lokhu kuyisibonakaliso sesibili sesifo esithile esiyimbangela. Ngakho-ke, ngaphambi kokwakha uhlobo lwemithi yokwelashwa, udinga ukuxilonga ngokunembile. Kodwa-ke, i-Riboxin iyona kanye isidakamizwa, ukuqokwa kwayo kwe-arrhythmias yanoma iyiphi i-genesis kuboniswa ngaphandle kokwesaba imiphumela emibi. Ukusetshenziswa kwayo ngamalungiselelo e-potassium kusebenza ngokukhethekile.

Ingqikithi yesenzo sayo ku-arrhythmia yehliselwe ekujwayeleni kwe-metabolism esiswini senhliziyo. I-Riboxin ingena ngokukhululekile kuwo wonke amaseli futhi, ikhulisa ibhalansi yayo yamandla, ibuyisela ukuqhutshwa okujwayelekile kwemizwa kagesi nge-myocardium. Lokhu kumisa i-arrhythmia.

Kumele kuqashelwe ukuthi umphumela onjalo ongenakuqhathaniswa enhliziyweni nasemithanjeni yegazi wenza umuthi ubaluleke kakhulu ekwelashweni okuyinkimbinkimbi kokugula kwenhliziyo. Kubandakanya phakathi kwesigaba esibucayi se-infarction ye-myocardial.

Muva nje, izindatshana zivele emaphephabhukwini ezokwelapha ukuthi iRiboxin iyi-placebo. Noma kunjalo, ukuzijwayeza kusho okuthile okuhluke ngokuphelele. Isenzo saso siqinisekiswe ukuhlolwa kwezilwane kanye nokuhlolwa kwemitholampilo.

Ukwelashwa kwesistimu yokugaya ukudla

I-Riboxin isuselwa ku-purine. I-phosphorylated, ingena kuma-hepatocyte, futhi iguqulwe ibe yi-inosinic acid. Le nto ingumthombo wama-nucleotide, i-adenyl ne-guanyl, enesibopho sokusebenza kohlelo lokugaya ukudla. Lapho usuthole izakhiwo zomgcini wepheshana lesisu, umuthi uyakuqinisekisa:

Ukwenza ngcono ukusabela okuxhomeke emandleni, ukudala isisekelo esiyisisekelo sezinqubo ze-redox, ukwakheka kwama-molecule we-macroenergetic, ukukhuthaza ukuphefumula kwezicubu, ukusetshenziswa kwama-lactates. Konke lokhu, kunjengokungathi, kuphinda imisebenzi yesibindi, kususe omunye umthwalo kulo.
Ukuhlanganiswa kokuxakaniseka okuphelele kwama-purine nucleosides adingekayo ekwakheni i-DNA ne-RNA. Lokhu kuvuselela izinqubo zokuzivuselela kuthubhu yokudla futhi kusize ukuguquguquka kokuguquguquka.

Ngokwenzayo, ukuguqulwa kwamakhemikhali okufakazelwe ngokwesayensi ezimweni zelebhu kuboniswa ekulungisweni kwemetabolism, ukususwa kwama-radicals wamahhala, ukwehla komsebenzi we-antitoxic, ukuvuselelwa okusheshayo kwezicubu zesibindi kanye ne-mucosa yesisu. I-Riboxin ikhonjiswa i-hepatitis kanye ne-cirrhosis yemvelaphi ehlukahlukene nasezigabeni ezahlukene zokuvuvukala kwezifo.

Ukuhambisana neminye imikhiqizo

I-Riboxin ayihambisani nhlobo notshwala, ikakhulukazi uma inikezwa amavithamini wabazali kanye nama-B, ikakhulukazi i-B6. Kodwa ingahlanganiswa ngaphandle kwezinkinga cishe zonke izidakamizwa ezinqunyelwe ukwelashwa kwezifo zenhliziyo, amasistimu wokugaya ukudla kanye nomchamo: i-Nitroglycerin, i-Concor, i-Renitek, i-Enapril, i-Nifedilin, i-Lasex, i-Furosemide.

Ukusetshenziswa kweRiboxin ekwakheni umzimba

Ukuqonda izinzuzo zamandla angeziwe alethwa yiRiboxin emzimbeni kuholele ekusetshenzisweni kwawo kabanzi emidlalweni yamandla edinga ukusetshenziswa kwamandla amaningi. Ukusetshenziswa kwezidakamizwa kuvumela:

Khulisa ukuhlushwa kwe-hemoglobin egazini kuya kunani elifanele, kucatshangelwa ukwenziwa kwezinto.
Khuthaza ukukhiqizwa kwe-insulin ngamanyikwe, okuqinisekisa ukumuncwa okulula kwama-carbohydrate yi-myocardium.
Lungisa ukukhanyisa kwemikhumbi ngokuya ngokungezwani, ukuyandisa.
Yenza kusebenze ukuzivikela.
Ukusheshisa ukuvuselelwa kwemisipha.
Khuphula amandla omsubathi.

Konke lokhu, ikakhulukazi ukukhuthazela, kubaluleke kakhulu ekwakheni umzimba. Ngaphezu kwalokho, iRiboxin ithuthukisa ukuhanjiswa kwegazi kuzo zonke izitho, kufaka phakathi lezo ezibhekele amandla, okubalulekile emadodeni.

Isimo se-multi-vector somuthi sikuvumela ukuthi umise ngokuphelele ukusetshenziswa kwamandla uma wenza izivivinyo zamandla, kuqinisekisa ukunikezwa kwe-oksijeni okujwayelekile, ngakho-ke, ukuphefumula kanye nokudla kwezicubu, okungukuthi, umzimba.

Kulokhu, umuntu akufanele akhohlwe ngomqondo wokulingana nokuqapha. Lokho wukuthi, ngaphambi kokusebenzisa i-Riboxin, kukhonjiswa ukuhlolwa okuphelele komtholampilo kanye nelabhoratri ukuze kuhlolwe isimo somzimba kanye nesidingo saso somuthi. Abasubathi abasebenzisa i-Riboxin bangakwazi ukubekezelela kalula i-hypoxia yomzimba, ngoba amaseli wezicubu amunca i-oxygen ngangokunokwenzeka. Ngesikhathi esifanayo, i-myocardium isebenza ngokuthula nangokuzethemba.

Ukusetshenziswa kweRiboxin kwezemidlalo

Ukuthandwa kweRiboxin phakathi kwabagijimi akuhlobene nakancane nomphumela wokwehla kwesisindo, njengoba kunjalo nangezinye izidakamizwa eziningi. Phesheya, i-inosine ifakiwe kwimenyu yabo bonke abasubathi. Lokhu kungenxa yokuthi akusho nje ukujwayeza umsebenzi izitho zangaphakathi main: inhliziyo. isibindi, izinso, kepha futhi kuvusa ukuzivikela komzimba, kwakha ukubekezelela okuphezulu emithwalweni emikhulu.

Njengoba i-Riboxin iyi-analogue ephelele ye-inosine, ibuye isebenze: iqinisa udonga lwe-vascular, ivimbela ukuqhekeka nokunwebeka kwemisipha nemisipha. Lokhu kuyaziswa kunoma yimuphi umdlalo, kepha ikakhulukazi phakathi kwe- "siloviki". Inzuzo engenakuphikwa yomuthi ukuthi ihlangabezana nazo zonke izidingo zokulwa nokusebenzisa izidakamizwa. Ngaphezu kwalokho, ukuphepha kwayo okuphelele kufakazelwe (ngaphandle kokungabekezelelani ngakunye) nokusebenza kahle ekululameni kwabasubathi ngemuva kokuzivocavoca umzimba ngokweqile.